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KMID : 0603820130190040303
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Journal of Experimental & Biomedical Science
2013 Volume.19 No. 4 p.303 ~ p.309
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Increased Antitumor Immunity of Mouse GM-CSF in Mouse Colon Tumor (CT-26) Model
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Kim Mi-Kyung
Lee Yu-Kyoung
Lee Yeon-Sook
Hwang Tae-Ho
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Abstract
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Oncolytic vaccinia virus is an engineered vaccinia virus that selectively destroys cancer cells and induces tumor immune response. Oncolytic vaccinia expressing mouse GM-CSF showed cytotoxic activity against various kinds of cancer cells when oncolytic vaccinia virus expressing human GM-CSF and mouse GM-CSF is intravenously administered in the mouse CT26 colon tumor model. Cancer cells treated with isolated immunoglobulin G from the serum with complement showed these cytotoxic activity and complement observed dose-dependent cytotoxic effect. These results suggest that oncolytic vaccinia virus expressing mouse GM-CSF can increase oncolytic vaccinia virus by inducing anticancer antibody in a mouse tumor model. Further studies are needed on antitumor immunity of GM-CSF.
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KEYWORD
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Antitumor immunity, Complement, GM-CSF, IgG, Oncolytic vaccinia virus
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